Endocrine Abstracts

Introduction: Melnick Needles Syndrome corresponds to a rare skeletal dysplasia of genetic etiology, with dominant inheritance pattern attached to the X chromosome. Mutations related to the gene of filamina A, which is responsible for the synthesis of collagen, are responsible for the clinical and phenotypic manifestations of the disease, with predominantly female involvement. Rickets are caused by inadequate mineralization of the bone, which precedes the closure of the epiphy...

Lentigo malign melanoma corresponds to the main histological type of melanomas ‘in situ’, particularly affecting Caucasian elderly exposed chronically to the ultraviolet rays. The therapeutic course should be surgical, with careful resection of the tumor, allowing free and wide margins. Follicular thyroid carcinoma corresponds to the second most common histological type characterized as a well differentiated neoplasm. It presents markedly vascular dissemination, bein...

GH secreting adenomas could be associated with clinical acromegaly with or without hyperprolactinemia, being rare cases of non functioning adenomas. They correspond a 25–30%of pituitary adenomas, generaly presented as macroadenoma.Frequently, they have another hormones production, often prolactin and TSH. Almost 75% of cases are macroadenomas. A 48-year-old Caucasian patient admitted complaining of facial craniofacial alterations, polyarthralgia, holocranial headache and ...